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Best Regional Mexican Restaurants in Little Italy

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8 restaurants available nearby

A photo of Rumorosa restaurant
1. Rumorosa
4.1
Excellent(23)
Price: Expensive
• Regional mexican • Harbor Island
Booked 2 times today
Located inside the Sheraton San Diego Hotel & Marina, Rumorosa is a brand-new concept by Executive Sous Chef Cesar Oceguera. Fusing the vibrant and bold flavors of Baja, Mexico, with a relaxed, yet playful San Diego vibe, the restaurant has floor to ceiling waterfront views.Born and raised on both sides of the border, Chef Oceguera infuses his aptitude for bold, Baja-inspired flavors into Rumorosa’s breakfast, lunch, and dinner menus featuring reimagined all-day classics served alongside inventive and authentic Cali-Baja dishes.Join us for a Baja-inspired Happy Hour at Rumorosa from 4 - 7 PM Monday - Friday, where vibrant flavors and our coastal atmosphere blend seamlessly. Indulge in unique Cali-Baja fusion dishes, paired perfectly with refreshing cocktails and Mexican wines. Also enjoy live music Thursday - Sunday, our signature Baja Breakfast Buffet during the week, and incredible Sunday Brunch.
A photo of El Agave restaurant
2. El Agave
4.7
Exceptional(2461)
Price: Moderate
• Regional mexican • Old Town
Booked 15 times today
El Agave in Old Town, San Diego, is a beacon of Contemporary Mexican cuisine, delighting patrons with its authentic and upscale offerings since 1996. Celebrated for housing the largest tequila museum in the U.S., this restaurant offers more than just a meal; it's a cultural experience. Diners rave about the "top tier authentic Mexican food" and the unbeatable atmosphere that makes every visit memorable. Favorite dishes like the ribeye tacos, tequila shrimp, and sopecitos are consistently praised for their excellence. As described by a satisfied guest, "the food, service, and drinks were phenomenal!" El Agave's commitment to quality and authenticity makes it a standout destination for those seeking the best in Mexican cuisine.
A photo of Blanco Cocina + Cantina - Coronado restaurant
3. Blanco Cocina + Cantina - Coronado
4.7
Exceptional(123)
Price: Moderate
• Regional mexican • Coronado
Booked 33 times today
Secure your spot and experience Blanco’s fresh twist on Mexican food. Lounge long and on with tantalizing tequila flights and easy but innovative tacos. Go for the classic but fresh burrito or bowl layered with savory fillings like spicy Machaca short rib or red chili chicken, fresh salsas, and our famous house guacamole. Whether you’re hungry for something flavorful or thirsty for something fun, we’ve got everything you want at Blanco.
A photo of Blind Burro restaurant
4. Blind Burro
4.5
Awesome(672)
Price: Moderate
• Regional mexican • Downtown / Gaslamp
Booked 3 times today
At The Blind Burro in Downtown San Diego, the spirit and flavors of contemporary Mexican cuisine come alive. Nestled in the vibrant East Village, this restaurant stands out for its fresh, coastal Baja-inspired dishes, which guests adore for their authenticity and creativity. Praised for its exceptional service and lively atmosphere, The Blind Burro offers an array of standout dishes, from sizzling surf & turf tacos to the beloved carne asada chimichangas, described by a patron as "phenomenal." Another diner raved, "The best chips and variety of salsas. Delicious drinks such as the sangria and Margarita on the rocks. Highly recommend the lobster tacos. To die for!" It's clear why this spot is a local favorite, perfect for a pre-game meal or a casual meetup, making every visit a delightful culinary adventure.
A photo of Ortega's A Mexican Bistro restaurant
5. Ortega's A Mexican Bistro
4.5
Awesome(1014)
Price: Moderate
• Regional mexican • Hillcrest
Booked 2 times today
Ortega's A Mexican Bistro, nestled in the vibrant neighborhood of Hillcrest, San Diego, offers a culinary journey to Puerto Nuevo with its authentic Mexican and Southwestern flavors. Diners rave about the Baja style lobster and table side guacamole, calling it a "delicious" and "authentic" experience. The restaurant's festive design and Baja California-inspired menu, including dishes like Banana Crusted Huachinango and Chicken Mole, consistently impress guests. Reviews highlight the "warm and inviting" atmosphere and "friendly and attentive" staff, with one customer exclaiming, "The lobster meal, handmade guacamole, and margaritas are to die for!" Ortega’s stands out as a beloved spot for both locals and visitors, making it a must-visit for anyone craving genuine Mexican cuisine in San Diego.
A photo of Blanco Cocina + Cantina – Fashion Valley restaurant
6. Blanco Cocina + Cantina – Fashion Valley
4.8
Exceptional(558)
Price: Moderate
• Regional mexican • Mission Valley
Booked 6 times today
Blanco Cocina + Cantina in Mission Valley, San Diego is a vibrant oasis for cocktail lovers seeking a blend of creativity and tradition. Known for its exceptional Cocktail Bar, Blanco transforms every visit into a mini-vacation with its delightful concoctions. Guests rave about the "spicy skinny margaritas" and the "mango margarita," which is described as "refreshing" with a "smoky salt rim" that adds a unique twist. The atmosphere is consistently praised, with diners highlighting the upbeat and welcoming vibe perfect for "a great date night spot" or a "fun gathering with friends." Blanco's ability to merge a lively environment with meticulously crafted cocktails ensures an unforgettable experience for all its visitors.
A photo of Casa De Freds, Tacos y Tequila restaurant
7. Casa De Freds, Tacos y Tequila
4.4
Awesome(316)
Price: Moderate
• Regional mexican • Old Town
Booked 2 times today
Nestled in the heart of Old Town, San Diego, Casa de Freds, Tacos y Tequila offers a vibrant slice of Tex-Mex heaven. Since 2001, this festive spot has been a favorite for both locals and visitors, praised for its "amazing" molcajete and "best burritos in town!" The authentic Baja-infused menu shines with high-quality ingredients that bring out the bold and savory flavors typical of Tex-Mex cuisine. Diners rave about the "outstanding" tacos and the freshness of the margaritas, making it a must-visit for anyone seeking a genuine taste of Tex-Mex in San Diego. With a dog-friendly patio and a festive atmosphere, Casa de Freds is the perfect spot to enjoy great food and great times.
A photo of Mario's De La Mesa Restaurant restaurant
8. Mario's De La Mesa Restaurant
4.4
Awesome(3)
Price: Moderate
• Regional mexican • La Mesa
Booked 1 time today
Experience the heart of Sonora and Sinaloa at Mario's De La Mesa Restaurant, where every dish tells a story of tradition and culinary mastery. Nestled in the vibrant neighborhood of La Mesa, this family-owned gem stands out for its commitment to authenticity and freshness. Patrons rave about the "amazing pico de gallo" and "perfectly cooked shrimp," highlighting the careful attention to quality ingredients and homemade recipes. From the tantalizing machaca and eggs to the creamy jalapeño shrimp, every meal is a fiesta of flavors. As one customer put it, "If I could, I would give this place more than 5 stars. This would be my last meal if I got the death sentence." Mario's is not just a meal; it’s a memorable dining experience that keeps locals and newcomers alike coming back for more. Join us at Mario's for a taste of true Regional Mexican cuisine right here in La Mesa.
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

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