Enable JavaScript to run this app.
Skip to main content
OpenTable logo
  1. Home
  2. United States
  3. San Antonio

Best Southern American Restaurants in Medical Center

Price
Regions
Neighbourhoods
Top Rated
Dining Options
Seating Options
Accessibility

82 restaurants available nearby

A photo of Clementine restaurant
1. Clementine
4.8
Exceptional(495)
Price: Very Expensive
• Southern american • North Central
Booked 9 times today
At Clementine, we’re serving seasonal, innovative eats in a modern & lively atmosphere. Our team, led by John (2023 James Beard nominee for Best Chef: Texas) and Elise Russ, draws inspiration from diverse global flavors. Our ever-evolving menu guarantees fresh and exciting options, while our dishes like the White Mushroom Salad, Ricotta Cavatelli and Clementine Crunch Bar remain cherished favorites. Our beverage menu is small but mighty, carefully curated to include only the most delicious wines & beers from our absolute favorite producers expertly selected to elevate your dining experience. Want your own bottle? Our corkage fee is $35 per 750ml.Our Dining Room provides comfortable indoor seating, while the Kitchen Bar boasts an exciting vantage point overlooking our open kitchen, allowing you to witness the creation of each dish. For a change of scenery, our covered patio, is perfect for al fresco dining, complete with heaters and blankets to keep you cozy on those cool nights.
A photo of Alamo Biscuit Company & Panaderia restaurant
2. Alamo Biscuit Company & Panaderia
4.3
Awesome(8)
Price: Moderate
• Southern american • Northwest
Booked 4 times today
Alamo Biscuit Company & Panaderia, located in the Northwest of San Antonio, is a beacon of American cuisine with a delightful twist. Patrons rave about the "delicious and HUGE" meals, like the smoked brisket Benedict and the egg, cheese, and brisket biscuit, which are a testament to the restaurant's commitment to quality and generosity in portions. The ambiance, described as "inviting," complements the expertly crafted dishes that blend traditional American flavors with a Tex-Mex flair, creating a unique dining experience. Visitors consistently highlight the "excellent service" and the atmosphere that makes every dining experience memorable. Whether it's for the "light and fluffy pancakes" or the "homemade buttermilk flavor of biscuits," Alamo Biscuit Company & Panaderia is a must-visit for anyone seeking authentic and innovative American fare.
A photo of Dave & Buster's - San Antonio (Balcones Heights) restaurant
3. Dave & Buster's - San Antonio (Balcones Heights)
4.6
Exceptional(103)
Price: Moderate
• Southern american • Medical Center
Booked 5 times today
Each Dave & Buster’s has more state-of-the-art games than ever, more mouth-watering menu items and the most innovative drinks anywhere. From wings to steaks, we’ve got whatever suits your appetite and our premium bar assures we’re stocked to satisfy! Plus, you can watch your game on one of our massive HDTVs with epic stadium sound.
A photo of 54th Street Restaurant & Drafthouse - The Colonnade restaurant
4. 54th Street Restaurant & Drafthouse - The Colonnade
(0)
Price: Moderate
• Southern american • Medical Center
54th Street was founded in Kansas City, MO by Thomas E. Norsworthy in 1989. He envisioned a place that would accommodate a consistently crowded dining room as well as a lively bar crowd, while offering the quality food and drinks that exceed national chain competitors. At 54th Street, we believe that great food starts with fresh produce, high quality meats and ingredients and meals prepared from scratch. With our amazing range of scratch prepared menu items, we truly have something for everyone. The Five-Four promise is to forever uphold our tradition of serving generous portions of housemade food and drink at an honest price. 54th Street welcomes you for all occasions. Drop in for Happy Hour with friends, celebrate a special occasion, enjoy a family night out or fly solo! Ultimately, it’s your time. Join us, experience 54 and share the 54 experience with others.
A photo of Rock & Brews - San Antonio restaurant
5. Rock & Brews - San Antonio
4.5
Awesome(13)
Price: Moderate
• Southern american • North Central
Booked 6 times today
At Rock & Brews in North Central San Antonio, comfort food is elevated to an art form, delighting diners with its authentic American-inspired menu. Their dishes, crafted from scratch using locally sourced ingredients, promise a taste that's both genuine and innovative. The Gastro Pub burger, praised for its succulent combination of bacon, fried egg, and Swiss cheese, and the Nashville Hot Chicken Salad are particularly standout offerings. Patrons rave about the quality and flavor, with one noting, "the food was amazing." This unique blend of top-notch comfort food, an electric atmosphere, and exceptional service makes Rock & Brews a must-visit for anyone seeking a memorable dining experience in San Antonio.
A photo of Kona Grill - North Star restaurant
6. Kona Grill - North Star
4.2
Awesome(583)
Price: Moderate
• Southern american • North San Antonio
Booked 14 times today
Kona Grill at North Star Mall in North San Antonio is an exemplary destination for authentic American cuisine, combining classic grill favorites with a unique twist. This restaurant stands out for its "global menu of contemporary American favorites, award-winning sushi, and specialty craft cocktails in a polished, casual atmosphere" that patrons adore. The quality of their steak is often praised as "Absolutely the best steak in Texas!" along with their exceptional service, making it a go-to spot for both locals and visitors. Reviewers consistently highlight the staff's attentiveness and the vibrant atmosphere, making every dining experience memorable. Whether it's for a hearty brunch, a delightful dinner, or a lively happy hour, Kona Grill at North Star offers a perfect blend of quality, service, and American cuisine flair.
A photo of Red Lobster - San Antonio - NW Loop 410 restaurant
7. Red Lobster - San Antonio - NW Loop 410
4.4
Awesome(15)
Price: Moderate
• Southern american • North San Antonio
Booked 3 times today
Elevate your day at Red Lobster, where fun meets fancy and every meal is a celebration. Whether you’re marking a special occasion or treating yourself or your crew, Red Lobster is the perfect place to enjoy all your seafood favorites. Dive into our signature shrimp, wild caught lobster and crab, and more. Plus, a variety of fish and popular non-seafood items like our Cajun Chicken Linguini Alfredo. Looking for a showstopper? Create Your Own Ultimate Feast or select a Live Maine Lobster straight from the tank. Or explore our Daily Deals with a different special available each weekday at a price you’ll love. Toast the day with Signature Cocktails including Lobster Punch and Main Deck Margarita Flights to make any moment feel festive. You won’t want to miss our newest menu items or special promotions like Lobsterfest and Crabfest. Reserve online today. Group Dining, To Go, or Catering options. For parties of 11+, please call.
A photo of Pinstack - San Antonio - Park North restaurant
8. Pinstack - San Antonio - Park North
3.8
Excellent(26)
Price: Moderate
• Southern american • Victoria
Booked 5 times today
Pinstack in Park North, San Antonio, is a vibrant cocktail bar and entertainment hub that truly stands out. With an extensive list of craft cocktails, 24 draft beers, and 12 keg wines, it caters to all tastes, ensuring a premium bar experience. Patrons rave about the atmosphere and the quality of drinks, with one visitor exclaiming, "The Paloma Pop mocktail was perfect for someone that doesn't really like sweet drinks!" The dedication to providing a diverse and quality drink selection makes Pinstack a top destination for cocktail enthusiasts looking for an upscale, enjoyable night out in Victoria, San Antonio. Whether you're in for the bowling or the bumper cars, the cocktail experience here is not to be missed.
A photo of Perry's Steakhouse & Grille - San Antonio restaurant
9. Perry's Steakhouse & Grille - San Antonio
4.7
Exceptional(9345)
Price: Expensive
• Southern american • La Cantera
Booked 105 times today
Perry's Steakhouse & Grille in San Antonio's La Cantera neighborhood is a beacon of American cuisine, offering a genuine taste of culinary excellence. Known for its iconic, "Texas-sized" pork chops and an array of well-crafted dishes, Perry's provides a dining experience that leaves patrons raving about its quality and authenticity. As one diner exclaims, the pork chops are "always amazing," and another recommends not missing the Friday lunch special for a fulfilling experience. The ambiance, including views from Bar 79® and the attentive service, complements the delicious offerings, making Perry's a must-visit for those seeking the heart and soul of American dining in The River City.
A photo of Chart House Restaurant - Tower of the Americas restaurant
10. Chart House Restaurant - Tower of the Americas
4.5
Awesome(16570)
Price: Moderate
• Southern american • Downtown
Booked 132 times today
Dine in the heart of Downtown San Antonio at Chart House Restaurant, a haven of American cuisine that promises more than just a meal. Celebrated for both its culinary prowess and enchanting views, Chart House offers an array of finely-crafted American dishes, from fresh fish specialties to the sumptuous slow-roasted prime rib. Guests rave about the "delicious food and great service," with highlights including the "best key lime pie ever" and an original Hot Chocolate Lava Cake that perfectly concludes a memorable dining experience. Whether it's the stunning city vistas or the "exceptional service," Chart House provides a dining experience that consistently delights and surprises, making it a must-visit for locals and tourists alike.
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you
From verified diners like you

Explore OpenTable

Discover
OpenTable
  • About Us
  • Blog
  • Careers
  • Press
More
Our sites
Businesses
  • Delight more diners
  • Open for Business Blog
Join us on
  • Privacy Policy
  • Terms of Use
  • Cookies and Interest-Based Ads
  • Cookie Preferences
Copyright © 2024 OpenTable, Inc. 1 Montgomery St Ste 500, San Francisco CA 94104 - All rights reserved.
OpenTable is part of Booking Holdings, the world leader in online travel and related services.
Booking Logo
Priceline Logo
KAYAK Logo
Agoda Logo
OpenTable Logo