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Best Southern American Restaurants in Museum District

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154 restaurants available nearby

A photo of Lucille's restaurant
1. Lucille's
4.5
Awesome(2420)
Price: Expensive
• Southern american • Museum District
Booked 49 times today
Lucille's, nestled in Houston's vibrant Museum District, is a beacon of authentic American cuisine with a Southern twist. This charming restaurant, set in a 1920s mission-style home, masterfully combines traditional Southern recipes with innovative international flavors. Diners rave about the "bold flavors and delicious drinks," with standout dishes like the "Chili Biscuits" and "Oxtail Omelette" that are described as "life-changing" and "truly unique and wonderful." The atmosphere is "upscale yet relaxing," making it an ideal spot for brunch or a special dinner. With exceptional service and a commitment to culinary excellence, Lucille's is a must-visit for a genuine American dining experience.
A photo of Clark's Oyster Bar - Houston restaurant
2. Clark's Oyster Bar - Houston
4.9
Exceptional(466)
Price: Expensive
• Southern american • Montrose
Booked 70 times today
Clark's Oyster Bar in Montrose, Houston, is a shining gem of Contemporary American cuisine, delighting diners with its exquisite blend of fresh seafood and classic American dishes. This vibrant restaurant is renowned for its "amazing oysters and seafood," bringing flavors from places like Maine and the Pacific Northwest to the heart of Houston. Diners rave about the "delicious variety of oysters" and the "best cioppino ever," making it a must-visit for seafood aficionados. The light, airy ambiance, complete with a charming outdoor patio, offers a perfect setting to enjoy a "wonderful experience" with "great food and service." Whether you're savoring a classic lobster roll or indulging in a luscious key lime tart, Clark's promises an authentic and memorable Contemporary American dining experience.
A photo of Drake's Hollywood - Houston restaurant
3. Drake's Hollywood - Houston
4.5
Awesome(244)
Price: Very Expensive
• Southern american • Montrose
Booked 74 times today
Drake's Hollywood in Montrose, Houston, is a haven for steak aficionados, offering an experience that is as authentic as it is exceptional. Known for its “amazing” dry-aged Delmonico steaks, the restaurant consistently receives rave reviews for both its culinary offerings and vibrant ambiance. Diners frequently highlight the “mouth-watering” quality of the steaks, with one reviewer declaring it as “the best steak” they've ever tasted. Each steak is perfectly prepared, capturing the essence of Old Hollywood glamour with every bite. The impeccable service and lively atmosphere only enhance the dining experience, making it a must-visit destination for steak lovers.
A photo of Rosie Cannonball restaurant
4. Rosie Cannonball
4.8
Exceptional(82)
Price: Expensive
• Southern american • Montrose
Booked 47 times today
Rosie Cannonball in Montrose, Houston, is a vibrant celebration of authentic Italian cuisine, skillfully prepared with a focus on live fire cooking. The restaurant's wood-burning oven and grill bring out the best in their hand-crafted pastas and wood-fired pizzas, drawing rave reviews for their "perfection" and "top quality." The menu, inspired by fresh, local ingredients, pairs exquisitely with an Italian-centric wine list curated by Master Sommelier June Rodil. Diners consistently praise the "extraordinary" service and "exceptional" food, making it a beloved gem in the heart of Houston. With its lively atmosphere and delectable offerings, Rosie Cannonball promises an unforgettable Italian dining experience.
A photo of Hudson House - River Oaks restaurant
5. Hudson House - River Oaks
4.8
Exceptional(468)
Price: Moderate
• Southern american • River Oaks
Booked 69 times today
Hudson House - River Oaks is a seafood lover's paradise, bringing the authentic flavors of the East Coast to Houston with a flair for freshness and quality. The oysters, "flown in daily," are a testament to their commitment to providing only the best, and pair perfectly with their renowned "World’s Coldest Martinis." The reviews speak volumes, with diners raving about the "superb" raw oysters and the "best grilled redfish" they've ever had in Houston. The restaurant’s dedication to serving consistently delicious seafood makes it a standout choice for anyone craving an unforgettable seafood dining experience.
A photo of Eunice restaurant
6. Eunice
4.7
Exceptional(2660)
Price: Moderate
• Southern american • Upper Kirby / Shepherd Corridor
Booked 34 times today
Eunice, nestled in the vibrant Upper Kirby area of Houston, is a seafood lover's paradise, offering a tantalizing menu inspired by the rich flavors of South Louisiana. The restaurant's seafood dishes, such as the "best gumbo I ever had" and the "outstanding oysters," are frequently praised for their authenticity and quality, transporting diners straight to the Gulf Coast. Executive Chef Drake Leonards masterfully infuses European influences with local ingredients, creating a unique culinary experience that keeps guests coming back for more. The warm, inviting atmosphere and exceptional service make Eunice an unforgettable dining destination for seafood enthusiasts.
A photo of Milton's restaurant
7. Milton's
4.8
Exceptional(148)
Price: Expensive
• Southern american • Rice Village
Booked 51 times today
Milton's is a delightful culinary gem nestled in the heart of Rice Village, Houston, offering an exceptional blend of American and Italian-American cuisine that truly stands out. Known for "delicious food and perfect service," Milton's is celebrated for its homemade pastas, like the unforgettable mushroom pasta, and wood-fired meats that offer a comforting yet innovative dining experience. Guests rave about the "outstanding service and food quality," making it a must-visit for those seeking authentic American flavors with a twist. The vibrant atmosphere and impeccable service ensure that every visit is memorable, promising patrons a taste of true American dining excellence.
A photo of Kiss Houston restaurant
8. Kiss Houston
4.5
Awesome(307)
Price: Very Expensive
• Southern american • Northside
Booked 63 times today
Kiss Houston is a vibrant culinary gem nestled in Northside, Houston, celebrated for its exceptional Fusion/Eclectic cuisine. This restaurant uniquely blends diverse flavors and traditions, creating an elevated dining experience that delights the palate. Guests rave about its "unforgettable and most pleasured experience," highlighting the vibrant atmosphere and expertly crafted dishes. The menu is a culinary adventure, offering everything from "flavorful lamb chops" to Southern staples like "catfish grits and gravy." With a lively ambiance amplified by an amazing DJ and a team that delivers "great customer service," Kiss Houston stands out as a must-visit for those seeking a dynamic and memorable dining experience.
A photo of Perry's Steakhouse & Grille - River Oaks restaurant
9. Perry's Steakhouse & Grille - River Oaks
4.6
Exceptional(2526)
Price: Expensive
• Southern american • River Oaks
Booked 16 times today
Perry's Steakhouse & Grille - River Oaks offers an unparalleled American dining experience in the heart of Houston. Celebrated for its “legendary and massive” pork chop, Perry’s showcases the finest in American cuisine with a menu that consistently delights. The attention to detail and exceptional service make dining here a memorable occasion; as one reviewer notes, it's “everything we had hoped for and more.” The restaurant’s vibrant atmosphere, complemented by its expansive two-story design and vibrant Bar 79®, ensures a unique and inviting setting. Whether celebrating a special event or enjoying a casual meal, Perry’s delivers a “Rare and Well Done®” experience.
A photo of Grace's restaurant
10. Grace's
4.8
Exceptional(4377)
Price: Expensive
• Southern american • Upper Kirby / Shepherd Corridor
Booked 56 times today
Grace's, nestled in the vibrant Upper Kirby / Shepherd Corridor of Houston, offers an authentic Comfort Food experience that transports diners back to the heartwarming meals of their childhood. Inspired by Johnny Carrabba’s grandmother, Grace Mandola, the restaurant serves up exceptional dishes filled with "the best home style cooking in Houston." Guests frequently rave about iconic comfort dishes, like the "possibly the best chicken fried chicken I've ever eaten," paired with creamy mashed potatoes and jalapeño cream gravy. The charming atmosphere, coupled with outstanding service, creates a cozy haven for diners seeking both nostalgia and culinary excellence.
‘About the restaurant’ descriptions have been generated using an artificial intelligence model comprised of OpenTable proprietary data that has not been independently verified by OpenTable. The content is presented as-is, for informational purposes only.

See what locals rave about

From verified diners like you
From verified diners like you
  • AnneVIP
    Houston •38 reviews
    5.0
    Dined 1 day ago
    The fig salad was delicious. The chicken parmeson was so-so. Our waiter was delightful! Love Ouisie’s and having been going for years. Always a great lunch spot with friends.
    More info
    Ouisie's TablePrice: Moderate• American• Galleria / Uptown
    •
    4.8
  • Kathy
    Houston •26 reviews
    5.0
    Dined 2 days ago
    Best food I’ve had in a long time. Each dish was so delicious. Service was exceptional! We will be back!!!
    More info
    Late AugustPrice: Expensive• American• Midtown
    •
    4.7
  • Martha
    Exclusive •1 review
    5.0
    Dined 3 days ago
    First time eating at Graces and everyone in our party of six loved it! The Campencha and Sticky Ribs appetizers were so delicious! The chicken pot pie was perfectly seasoned and so very tasty. Other dishes ordered which were equally delicious were the shrimp tacos and the beef stroganoff. The restaurant ambience was enjoyable on this Tuesday evening, and it was easy to hold conversations around our table. The choice of either valet parking or the parking garage made parking easy! We are already planning our next visit to Graces and talking about the menu items we want to order!
    More info
    Grace'sPrice: Expensive• American• Upper Kirby / Shepherd Corridor
    •
    4.8
  • LeonardVIP
    Houston •39 reviews
    5.0
    Dined 3 days ago
    I treated my coworker to lunch with our team today to celebrate her work anniversary. Excellent experience and everyone enjoyed the lunch.
    More info
    Lucille'sPrice: Expensive• Regional American (Southern)• Museum District
    •
    4.5
  • Tenesha
    Houston •1 review
    5.0
    Dined on Mar 1, 2025
    The service was excellent. We went during brunch on a Saturday. We ordered what was recommended by the waiter catfish with grits and the fried chicken. It was delicious. We will be going back to try new dishes. Definitely, going to recommend to friends.
    More info
    Kulture RestaurantPrice: Expensive• Regional American (Southern)• Downtown
    •
    4.2

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