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M Brothers Restaurant - By the Medure Brothers - M Brothers at Mayo, Jacksonville, FL

M Brothers at Mayo

4.7
4.7
502 Reviews
$50 and over
Seafood

Make a reservation

2 people
7:00 p.m.
Booked 8 times today
Experiences are available.
  • Good for special occasions
  • Good for business meals
  • Fancy
Located inside Jacksonville's Mayo Clinic, M Brothers is the newest venture by the Medure Brothers, Chef Matthew and David Medure. Our menu has a focus on fresh seafood with an Asian and Mediterranean flair. Visit our lounge for a craft cocktail or select a bottle of wine from our extensive list. Serving Lunch and Dinner Monday - Saturday.

Dining areas

Additional information

  • Dining style
    Fine Dining
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Hours of Operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Phone number
    (904) 953-0409
  • Dress code
    Casual Dress

Experiences

  • Culinary Passport: Peru

    US$90.00 - US$135.00 per person

    Mar 22, 2025 only
    Join us at M Brothers on Saturday, March 22, 2025, for the next stop on our Culinary Passport Dinners series! Indulge in a 4-course tasting menu inspired by the vibrant and diverse flavors of Peru. From the zesty flavors to the heartwarming stews and unique Andean ingredients, this menu offers an elevated taste of Peruvian cuisine. This experience is priced at $90 per person, or enhance your meal with curated wine or alcohol pairings for each course for $135. This exclusive menu will ONLY be available on March 22nd. Don’t miss this unforgettable culinary adventure!
    Culinary Passport: Peru photo

What 502 people are saying

Overall ratings and reviews

Reviews can only be made by diners who have eaten at this restaurant

4.7
4.7 based on recent ratings
  • 4.7Food
  • 4.7Service
  • 4.6Ambience
  • 4.5Value

NoiseModerate

Loved For

  • Jacksonville / Northeast Florida

    Seafood

  • Jacksonville

    Best Food

Review summary

AI-generated from verified diner reviews
M Brothers at Mayo offers an exceptional dining experience "in an unexpected location," consistently praised for its "innovative, delicious" cuisine and "friendly, attentive" service. Guests enjoy a "welcoming ambiance" with live music, standout dishes like the Short Rib with Pappardelle, and an "extensive wine and cocktail menu." Highly recommended for a "wonderful dining experience!"

502 Reviews
  1. Robert

    Cleveland

    3 reviews

    4.0

    3 reviews

    Dined 2 days ago

    1. Overall 4
    2. Food 5
    3. Service 5
    4. Ambience 4
    The food was great, our waitress was fabulous (very accommodating, went above and beyond the call of duty, and funny!), but the hostess was rude. Send the hostess to hospitality training so that she can understand what that word means. Despite her rudeness, I would go back when I have an appointment at Mayo.

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  2. Carol

    VIP

    Jacksonville

    9 reviews

    5.0

    9 reviews

    Dined 4 days ago

    1. Overall 5
    2. Food 4
    3. Service 5
    4. Ambience 4
    We had a great meal in the style of the country of Turkey. Everything was delicious.

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  3. Michael

    Jacksonville

    1 review

    5.0

    1 review

    Dined 4 days ago

    1. Overall 5
    2. Food 5
    3. Service 4
    4. Ambience 5
    Another enjoyable evening with the ‘If it grows together’ parings chef has created. All courses from Turkey were wonderful, but the Smoky tomato sauce on the second course… he better make that a staple on the everyday menu or he is missing out on easy money. Always a great experience.

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  4. Clare

    VIP

    Jacksonville

    16 reviews

    5.0

    16 reviews

    Dined 4 days ago

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Excellent wine dinner -- creative cuisine and perfect pairings.

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  5. JP

    Jacksonville

    13 reviews

    4.0

    13 reviews

    Dined on February 18, 2025

    1. Overall 4
    2. Food 4
    3. Service 4
    4. Ambience 4
    Excellent food, service and ambience. We always lunch at M Brothers when we visit the Mayo Clinic.

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  6. Teri

    Jacksonville

    1 review

    5.0

    1 review

    Dined on February 18, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    We enjoyed our delicious lunch and excellent service. Highly recommend!
    M Brothers at MayoResponded 5 days ago
    Thank you for the kind words! We're so glad you enjoyed your lunch and the service. We appreciate the recommendation and look forward to having you back soon!

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  7. Sean

    Jacksonville

    1 review

    1.0

    1 review

    Dined on February 16, 2025

    1. Overall 1
    2. Food 2
    3. Service 1
    4. Ambience 3
    We decided to try M Brothers at Mayo, even though it's in a weird location, because we are fans of all Medure Brothers restaurants. Restaurant Medure is one of our favorite restaurants at the beaches and we were frequent guests at M Shack AB before it closed. Unfortunately, this was one of the worst fine dining experiences we've had in a long time. After we were seated, it was 10 minutes before our server, or anyone, came by. Our server rarely came to our table after that. We ordered a couple cocktails (which were OK) and we weren't in any hurry but she came so infrequently that at one point we asked her to please leave a pitcher of water so we could serve ourselves. After an appetizer of fish bites (which were pretty good) she took our utensils. While we were waiting for our utensils, the table next to us returned their entree because it had a long hair in it. Our main dish was delivered 15 minutes later and she hadn't come back and we still didn't have utensils. My main dish was a half rack of lamb and it was pretty good but nothing exceptional. My wife ordered the prime ribeye (rare) with twice baked potato. The steak was tough and full of gristle. The "twice baked potato" was half a potato with some toppings on top, not an actual twice baked potato. Worse yet, the potato was undercooked so it was still hard. My wife couldn't eat much of her entree, despite really trying. She rarely complains, but she was excited about the entree and was really disappointed. To their credit, we told them about the steak and potato and they sent it back to the chef. He agreed it wasn't to their level of quality and took it off our bill, but the poor service and bad entree made for an overall poor experience. We won't ever be back. It makes us appreciate our experiences at Restaurant Medure a little more.

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  8. Van

    Jacksonville

    7 reviews

    5.0

    7 reviews

    Dined on February 15, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    Nice place, recommend 10 out of 10 times. Service was excellent.
    M Brothers at MayoResponded 5 days ago
    Thank you for the glowing review! We're thrilled to hear you had a great experience. We truly appreciate your recommendation and look forward to having you back soon!

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  9. Michael

    Jacksonville

    8 reviews

    5.0

    8 reviews

    Dined on February 15, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 4
    We were not 100% sure what to expect with the restaurant being located in the atrium of the Mayo Hospital Cannaday Bldg. Beautifully designed Lounge and Dining room areas are what we discovered, Live music ( Sax Player) and a real candle on the table. Great service, outstanding apps, dinner and dessert. We would highly recommend M Brothers at Mayo to anyone who is in search of a great dining experience.
    M Brothers at MayoResponded 5 days ago
    Thank you so much for your wonderful review! We're thrilled that you enjoyed the atmosphere, live music, and your entire dining experience. Your recommendation means a lot to us, and we can’t wait to welcome you back for another fantastic evening!

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  10. Rebekah

    VIP

    Jacksonville

    63 reviews

    5.0

    63 reviews

    Dined on February 14, 2025

    1. Overall 5
    2. Food 5
    3. Service 5
    4. Ambience 5
    This remains our favorite restaurant in Jacksonville area. Service is always welcoming, accommodating and helpful. I have to add, they are so friendly and recognize us with each visit. The food is innovative, delicious and awesome! The cocktails are some of the best we've had. Wine selection has all our favorites. So glad to have this laid back, beautiful, hidden gem. I hate to give it the praise it deserves because I love it's easy to book and get in, but people need to know!
    M Brothers at MayoResponded 5 days ago
    Thank you so much for your kind words! We're thrilled to be your favorite restaurant in the area and so glad you enjoy the food, cocktails, and service. We truly appreciate your support and promise to keep delivering that same great experience each time you visit. Thank you for helping spread the word! We look forward to welcoming you back soon!

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FAQs

M Brothers at Mayo is rated 4.7 stars by 502 OpenTable diners.

Yes, you can generally book this restaurant by choosing the date, time and party size on OpenTable.

Make a reservation

2 people
7:00 p.m.
Booked 8 times today
Experiences are available.
Google Map for M Brothers at Mayo

14335 Hospital Drive Suite 100, Jacksonville, FL 32224

Dining areas

Additional information

  • Cross Street
    San Pablo to W. Davis. Turn into Garage and look for complimentary VALET.
  • Neighbourhood
    Jacksonville
  • Hours of Operation
    Lunch Mon–Fri 11:00 am–2:00 pm Dinner Mon–Sat 5:00 pm–9:00 pm
  • Price
    $50 and over
  • Cuisines
    Seafood, Asian, Mediterranean
  • Dining style
    Fine Dining
  • Dress code
    Casual Dress
  • Parking details
    Valet
  • Additional
    Bar/Lounge, Chef's Table, Non-Smoking, Private Room
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  • Terms of Use
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